罗曼蒂克消亡史

Chinese researchers identify target to develop depression drug using traditional ethnic medicine in Yunnan_我的网站

A |     南北交通廊道的地面街道将重新打造为结合活跃通勤、活化社区和绿意的走道，并以社区和工业、生态、养生及文化遗产四大主题划分。

B |     

    Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.  
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia. 
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
    An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
。陆路交通管理局今天宣布，把南北交通廊道地面街道总蓝图的咨询合同颁发给国际建筑事务所Henning Larsen及伙伴。总蓝图预计2026年完成，地面街道的改造工程预料从2027年起分阶段展开。南北交通廊道地面街道重新打造。（图：陆路交通管理局）南北交通廊道地面街道重新打造。（图：陆路交通管理局）南北交通廊道地面街道重新打造。（图：陆路交通管理局）南北交通廊道地面街道重新打造。（图：陆路交通管理局）根据Henning Larsen提出的初步概念，南北交通廊道的地面街道将分为四段。其中，在市区一带3.5公里长的文化遗产段，梧槽干拿路、双溪路和惹兰勿刹交界处将被打造成地标性公共空间，衔接小印度、甘榜格南和滑铁卢街三大文化区，以及附近的教育学府，包括拉萨尔艺术学院、南洋艺术学院及新加坡管理大学校园；毗邻甘榜格南的奥菲亚路部分路段则可能改为行人步道。涵盖义顺、宏茂桥一带的生态段则长达七公里，初步概念包括：将宏茂桥一带的南北交通廊道地面街道打造成自然主题公共空间、脚踏车道、步道和游乐区，衔接附近的邻里及碧山-宏茂桥公园。

C | 北部的社区工业段的初步概念则拟议在甘巴士道的汽车天桥下，开辟包括游乐设施和装置艺术作品的休闲公共空间。

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Published on:04:31:11